Yaya tsawon lokacin da ya ɗauka don HPMC ya narke?

HPMC (Hydroxypropyl methylcelrose) shine abin da aka saba amfani da polymer da ake amfani da shi a cikin shirye-shiryen allunan magunguna, ido saukad da sauran samfuran. Lokacin rushewa ya dogara da dalilai da yawa, gami da nauyin kwayoyin, zazzabi na bayani, da sauri da taro.

1. Nauyi mai nauyi da kuma yanayin canji
Girman kwayar halitta da kuma yanayin maye (watau metoxypypyl abun ciki) na HPMC zai shafi warwarewarsa. Gabaɗaya magana, mafi girma ƙwayar ƙwayoyin cuta, tsawon lokaci yana ɗauka don narke. Weɓaɓɓiyar ciwon HPMC (ƙananan nauyin ƙwayoyin cuta) galibi yana ɗaukar minti 20-40 don narke a ɗakin zafin jiki, yayin da babban danko) na iya ɗaukar sa'o'i da yawa don yin yawa.

2. Maganin zazzabi
Yawan zazzabi na maganin yana da tasiri mai tasiri akan kashewar HPMC. Ruwan zafi mafi girma yawanci sauri tsari tsari, amma yanayin zafi wanda ya yi yawa yana iya haifar da lalata HPMC. Gabaɗaya shawarar da aka lalata shi shine tsakanin 20 ° C da 60 ° C, kuma takamaiman zaɓi ya dogara da halayen HPMC da kuma dalilin amfani.

3. stringing sauri
Motsa jiki na iya inganta rushewar HPMC. String da kyau na iya hana agglomeration da hazo na HPMC kuma sanya shi a hankali a cikin mafita. Za a gyara zabin saurin mai motsawa gwargwadon takamaiman kayan aiki da kuma halayen HPMC. Gabaɗaya, ana iya samun sakamako mai gamsarwa ta motsa jiki na minti 20-40.

4. Bayani na bayani
A maida hankali ne na HPMC shima mai mahimmanci ne wajen tantance lokacin rushewa. A mafi girma da maida hankali, ya fi tsayi da rushewar yawanci shine yawanci. Don ƙarancin taro (<2% w / w) mafita na HPMC, lokacin da aka rushe na iya zama gajeru, yayin da mafi girman ƙarfin maida hankali ke buƙatar ƙarin lokaci don narke.

5. Zabi mai yiwuwa
Baya ga ruwa, ana iya narkar da HPMC a wasu abubuwan da sauran ƙarfi kamar ethanol da Ethylene glycol. Polarity da solubility daban-daban hanyoyin da zasu iya shafar raguwar hpmc da kuma halayen maganin ƙarshe.

6. Hanyoyin Takaddun
Wasu hanyoyin da suka dace, kamar su hpmc mai wrodrc ko ta amfani da ruwan zafi, na iya taimakawa wajen hanzarta tsarin rushewarsa. Bugu da kari, amfani da musayar cutar kan kamar Surfacts na iya inganta ingancin rushewa.

Lokacin rushewar HPMC ya shafi abubuwa da yawa. Sabili da haka, a aikace-aikace na aiki, ya kamata a daidaita yanayin rushewar takamaiman buƙatun amfani da kuma halayen HPMC. Yawanci, lokacin da ake buƙata don HPMC don narkewa a ƙarƙashin yanayin da ya dace yana fitowa daga minti 30 zuwa sa'o'i da yawa. Don takamaiman samfuran HPMC da yanayin aikace-aikacen, ana bada shawara don komawa zuwa ga umarnin samfurin ko yin gwaje-gwajen rushewa da lokaci mafi kyau.