1. Ainihin kaddarorin HPMC
Hyfomomlose, turanci sunan hydroxypropyl methylcellulhin, a ceias hpmc. Tsarin ƙwayoyin jikinta yana c8h15o8- (C10HL8O6) n-c8hl5o8) Ana iya samar da shi ta hanyoyi guda biyu: ɗayan shine cewa matakin da ya dace na Prepylene ana bi da shi tare da Na'ha, sannan kuma an mayar da shi tare da propylelene opylelene opide a karkashin babban zazzabi da matsin lamba. An haɗa kamannin da aka haɗa da zobe na fari, kuma yana iya kai matakin da ya dace; Sauran shine kula da likkoki auduga ko katako na fiber tare da soda na caustic soda, sannan kuma sake fasalin dethyl kuma don samun foda mai kyau ko granules. HPMC wani iri-iri na tsire-tsire na halitta ne, kuma shi ne kuma kyakkyawan aikin magunguna, wanda ke da wurare da yawa da yawa. A halin yanzu, ana yi amfani da shi sosai a gida da kuma kasashen waje, kuma yana daya daga cikin magudi mai amfani da mafi girman amfani da magunguna na baka.
Wannan samfurin shine fari ga fari na fari a launi, wanda ba mai guba da m, kuma yana cikin hanyar foda ko fibrous wanda ke gudana sauƙi. Yana da ban tsoro a ƙarƙashin bayyanar haske da laima. Yana kumbura a cikin ruwan sanyi don samar da wani madara mai narkewa mai kyau, wanda ke da takamaiman haɗin danko, da kuma sabon mai haɗin gwiwar Sol-gel na iya faruwa saboda canjin zafin jiki na takamaiman bayani na mafita. Yana da matukar narkewa a cikin 70% barasa ko Dimethyl ketone, kuma ba zai narke cikin cikakken barasa, chlorixyhane ko ethoxyethane ba.
A lokacin da ph na hypromoghose yake tsakanin 4.0 zuwa 8.0, yana da kyakkyawar kwanciyar hankali, kuma yana iya wanzuwa lokacin da pH yake tsakanin 3.0 zuwa 11.0. Lokacin da zazzabi ke 20 ° C da kuma yanayin dangi shine 80%, an adana shi tsawon kwanaki 10. Danshi clephendaddamar da hpmc ne 6.2%.
Saboda abinda ke ciki na metoxy da hydroxypropyl a cikin tsarin hyppomomolose, daban-daban iri samfuran sun bayyana. A takamaiman taro, nau'ikan samfuran suna da takamaiman danko da yanayin zafi, sabili da haka, suna da kaddarorin daban-daban kuma ana iya amfani da su don dalilai daban-daban. Proppopopoeias na ƙasashe daban-daban ƙasashe suna da ƙa'idodi daban-daban da wakilci na Turai a kan samfuran viscosies da lambobi daban-daban da aka sayar a cikin kasuwar, kuma naúrar MPAFE; A cikin Kasar Amurka, sunan gama gari suna ƙara lambobi 4 a ƙarshensu don nuna abubuwan da suka dace da Hydroxypoyl na ƙarshe.
2. Hanyar narkar da HPMC a cikin ruwa
2.1 Hanyar ruwa mai zafi
Tunda hyppomomelose baya narke a cikin ruwan zafi, ana iya rarrabe shi cikin ruwan zafi a farkon, sannan ya sanyaya. Hanyoyin hali na hali sun bayyana kamar haka:
(1) Sanya adadin ruwan zafi a cikin akwati, kuma zazzabi shi zuwa kimanin 70 ° C, a hankali yana bunkasa wannan samfurin a cikin jinkirin ruwa, sannan kuma hankali ƙara wannan samfurin, motsawa a hankali ya sanya slurry, sannu a hankali ya sanya slurry ƙasa.
(2) ƙara 1/3 ko 2/3 na yawan ruwa a cikin akwati kuma ya kai shi zuwa 70 ° C don watsa samfurin ruwan sanyi, sannan a ƙara sauran adadin ruwan sanyi ko ruwa mai ruwan sanyi a cikin siliki mai zafi, cakuda ruwan sanyi, cakuda yana sanyaya bayan motsawa.
2.2 foda
Barbashi foda suna rarrabe ta bushe bushe tare da daidai ko daidai adadin kayan masarufi, sa'an nan kuma narkar da cikin ruwa. A wannan lokacin, ana iya narkar da hyppomochose ba tare da agglomeration ba.
3. Abincewar HPMC
3.1 Cold ruwan sanyi
Solrable a cikin ruwan sanyi a ƙasa 40 ° C ko 70% ethanol, m instolable a cikin zafi ruwan sama sama da 60 ° C, amma ana iya juyawa.
3.2 sunadarai
Hypromchose (HPMC) wani nau'in sel mai kyau na ionic. Maganinta bashi da caji Ionic kuma baya hulɗa da salts na ƙarfe ko ionic kwayoyin halitta. Saboda haka, wasu masu complifies ba su amsawa da shi yayin aiwatarwa.
3.3 Duri
Yana da in mun gwada da acid da acid da alkali, kuma ana iya adanar na tsawon lokaci tsakanin PH 3 da 1l ba tare da canji a cikin danko ba. Maganin ruwa mai ruwa na ruwa mai ruwa na ruwa (HPMC) yana da tasirin anti-mildew kuma yana iya kula da kyakkyawan yanayin gani yayin ajiya na dogon lokaci. Pharmaceuticals ta amfani da HPMC azaman chepsfies suna da inganci mai inganci fiye da waɗanda suke amfani da compifient na gargajiya (kamar Dextrin, sitaci, da sauransu).
3.4 GASKIYA Daidaitawa
Za'a iya hade da kayan kwalliyar HPMC daban bisa ga HPMC daban bisa ga Ratios daban-daban, kuma amsar ta na iya canzawa bisa ga wasu ƙa'idodi, kuma yana da kyakkyawar dangantaka mai kyau, don haka yana da kyakkyawar dangantakar ma'anar.
3.5 metabolis inertia
HPMC ba ta sha ko metabolized a cikin jiki, kuma baya bayar da zafi, saboda haka ba karamin tsari ne na aikin magunguna ba.
3.6 tsaro
Gabaɗaya an yi imani da cewa hpmc wani abu ne mai guba da mara haushi. A cikin Mice na Mice na Mice shine 5g / kg, kuma Median na mutuwa na Mediya don berayen ne 5.2g / kg. Allurai na yau da kullun marasa lahani ga mutane ne.
4. Aikace-aikacen HPMC a cikin shiri
4.1 a matsayin kayan fim da kayan samar da fim
Ta amfani da hypromocose (HPMC) azaman kayan kwalliya-mai rufi da aka rufe shi kamar Allunan gargajiya, tsinkayen kayan kwalliya ba su da kyau da kuma wasu alamun ingancinsu sun fi kyau. Ana amfani da darajan daraja na wannan samfurin a matsayin kayan fim mai narkewa don allunan da kwayoyi, da kuma mahimmin girma-danko. Cikakkar daɗaɗa yawanci 2.0% zuwa 20%.
4.2 a matsayin Bodind da Drointrant
Za'a iya amfani da matakin girma na wannan samfurin azaman mai sanyaya da watsawa don allunan, ƙwayoyin, da kuma granulles, da granulles, da granulles, da kuma granules. Sashi ya bambanta da samfura daban-daban da buƙatu. Gabaɗaya, sashi na m goge don bushe allunan allunan ne 5%, da kuma sashi na bindind don rigar grinarth shine 2%.
4.3 a matsayin wakili mai dakatarwa
Wakilin dakatarwa shine kayan kwalliya na viscous tare da hydrophilicicity, wanda zai iya rage saurin saurin sutturwar, kuma ana iya haɗe shi zuwa saman wakilin da aka yi amfani da shi don hana barbashi daga haduwa da raguwa a cikin ƙwallo. An dakatar da wakilai suna taka muhimmiyar rawa wajen yin shawarwari. HPMC ingantacciyar ingantacciyar nau'ikan wakilan wakilan, kuma an narkar da mafita na zamani ta hanyar samar da ruwa mai ƙarfi, ta yadda ke inganta tsarin watsawa na heterogeneous. Ana amfani da matakin girma na wannan samfurin azaman shirye-shiryen dakatarwar ruwa wanda aka shirya a matsayin wakili mai dakatarwa. Yana da kyakkyawan dakatar da sakamako, yana da sauƙin daidaita, baya sanyawa ga bango, kuma yana da kyawawan barbashi mai kyau. Rana na yau da kullun shine kashi 0.5% zuwa 1.5%.
4.4 a matsayin mai ba da izini, mai saki da saki da pore-haifar wakili
Za a yi amfani da matakin ban sha'awa na wannan samfurin don shirya allunan saki mai ɗorewa don sakin allurar sakin abu, kuma yana da tasirin jinkirin sakin magani. Amfani da hankali shine 10% ~ 80% (w / w). Ana amfani da babban grade low-danko a matsayin wakilai masu samar da abubuwan da aka sanya don ci gaba da saki ko shirye-shiryen saki. Za a iya amfani da kashi na farko don tasirin warkewa na wannan nau'in kwamfutar hannu za a iya ci gaba da sauri, sannan kuma yana haifar da sakamako mai ɗorewa, kuma ana kiyaye tasirin magunguna cikin jiki. A lokacin da hyprommococose ya gana da ruwa, yana hykery don samar da gel Layer. Hanyar sakin magani daga kwamfutar hannu matrix yafi haɗa da yaduwar gel na gel da kuma lalacewa na gel Layer.
4.5 manne mai kariya kamar kauri da colloid
Lokacin da ake amfani da wannan samfurin azaman tsawa, maida hankali ne da aka saba amfani dashi shine 0.45% ~ 1.0%. Wannan samfurin zai iya ƙara haɓakawa na manne mai kariya, samar da ingantaccen Colloid, da kuma maida hankali, da kuma taro na yau da kullun shine 1.5% ~ 1.5%.
4.6 kayan kwalliya don capsules
Yawancin lokaci capsule harsashi Capsule kayan capsule ya dogara ne akan Gelatin. Tsarin samar da gelatin capsulle kwasfa mai sauki ne, amma akwai wasu matsaloli da abubuwan da ba su dace ba, karancin karuwa, da jinkirta rarrabuwa da karami na capsule a lokacin ajiya. Don haka, hypppromlocese, a matsayin madadin gelatin capsules, ana amfani dashi a cikin shirye-shiryen capsules, kuma an inganta shi a gida da kuma kasashen waje.
4.7 a matsayin bioaddheve
Fasahar biewheion, amfani da compifies tare da manufofin bioadhheive, ta hanyar ci gaba da kuma mucosa, saboda haka, da mucosa ya saki mashin da mucoape ya saki don cimma dalilai na warkewa. A halin yanzu ana amfani dashi ana amfani dashi don magance cututtuka na hanci, na baka mucosa da sauran sassan. Fasahar biormesinal na ciki shine sabon tsarin isar da magani a cikin 'yan shekarun nan. Ba wai kawai tsawanta lokacin zama na shirye-shiryen magunguna a cikin gastrointestestinal fact, amma don inganta aikin ƙwayoyin sel da sel membrane, don haka inganta shi na ƙwayoyin cuta.
4.8 a matsayin taken
A matsayinka na kayan adon fata, gel yana da jerin fiyya kamar lafiya, kyakkyawa, mai sauƙin tsabtatawa, ƙarancin farashi, tsari mai sauƙi tare da kwayoyi. shugabanci.
Lokacin Post: Feb-14-2225