Hydroxypyl methylcelose (HPMC) da methylcellulose (MC) dukansu masu samar da sel na sel ba su da amfani sosai a aikace-aikacen Pharmaceutical saboda abubuwan da suka dace. Duk da kamanninsu, suna da bambance-bambance daban-daban a cikin tsarin sunadarai, kaddarorin, da aikace-aikace waɗanda suka sa su dace da manufofin daban-daban a masana'antar magunguna.
Abubuwan sunadarai da tsari
Hydroxypyl methylcelos (hpmc):
HPMC ce ethuliyy mai canzawa. It is derived from cellulose by treating it with methyl chloride and propylene oxide, which introduces methoxy (-OCH3) and hydroxypropyl (-CH2CHOHCH3) groups into the cellulose backbone. Matsayi na musanya (DS) da kuma sasalin molar (MS) ƙayyade rabo daga cikin waɗannan ƙungiyoyin. DS yana wakiltar matsakaiciyar hydroxyl ƙungiyoyi waɗanda suka sauya ɓangaren ukhydroguse, yayin da ms ke nuna matsakaicin adadin ƙungiyoyin hydroxypolyl da aka makala.
Methylcellulose (MC):
MC wani yanki ne na sel, amma ba a inganta shi idan aka kwatanta da HPMC ba. An samar dashi ta hanyar kula da selulose tare da Methyl chloride, wanda ya haifar da musanyawa ƙungiyoyin hydroxyl tare da ƙungiyoyi metoxy. Wannan gyaran ana amfani da shi ta hanyar rarrabuwa (DS), wanda, don MC, yawanci jere daga 1.3 zuwa 2.6. Rashin kungiyoyin hydroxypyl a cikin MC ya bambanta ta daga HPMC.
Properties na jiki
Sallasio da Gelent:
HPMC yana da narkewa a cikin ruwan sanyi da ruwan zafi, samar da mafita mafita. Da dumama, HPMC ya yi lalata da menmoregoreves da muni, ma'ana yana siffofin gel lokacin da aka mai zafi da komawa zuwa mafita a kan sanyewa. Wannan kadara tana da amfani musamman a cikin sakin magani da aka saki kuma a matsayin mai tasoshin ra'ayi a cikin mafita mafita.
MC, a gefe guda, yana narkewa a cikin ruwan sanyi amma insolable a cikin ruwan zafi. Hakanan yana nuna haɓakarsa; Koyaya, zazzabi na gashinta yana ƙasa da na HPMC. Wannan halayyar tana sa MC ta dace da takamaiman aikace-aikacen magunguna inda ƙananan ƙarancin ƙwayar cuta yake da amfani.
Daidaitawa:
Dukansu HPMC da MC na iya haɓaka danko na mafita na mafita, amma HPMC gabaɗaya yana ba da kewayon vicoosies saboda yanayin sauya bambance bambancen ra'ayi. Wannan bambance-bambancen yana ba da damar amfani da ingantaccen tsari a cikin tsari na buƙatar takamaiman bayanan martaba na danko.
Ayyuka a cikin magunguna
HPMC:
Mai sarrafawa sakin matrix matrix:
An yi amfani da HPMC sosai a cikin sarrafawa matrix matrix. Iyakar sa na zubar da kuma samar da gel Layer a kan lamba tare da rukunan ruwan ciki yana taimakawa wajen sarrafa darajar sakin magani. Gel Layer yana kan aiki azaman shamaki, yana iya haɗaɗɗun yaduwar magani da kuma shimfida sakin sa.
Filin Markon:
Saboda shi ne da ingantaccen kayan fim, ana amfani da HPMC sosai a cikin shafi allon da pellets. Yana ba da shinge mai kariya daga danshi, oxygen, da haske, yana haɓaka kwanciyar hankali da kuma rayuwar samfurin. Ari ga haka, ana iya amfani da riguna hpmc don ɗanɗano masking kuma don inganta bayyanar allunan.
M a cikin tsarin kwamfutar hannu:
Hakanan ana amfani da HPMC azaman mai ba da labari a cikin rigar gunaguni. Hakan yana tabbatar da ƙarfin kayan adon da Allunan, yana sauƙaƙe ɗaure barbashin barbashi yayin matsawa.
Dakatar da Thickening wakili:
A cikin samarwa ruwa, HPMC tana aiki a matsayin dakatarwa da wakili na tsinkaye. Babban dankalinta yana taimakawa wajen rike rarraba rarraba barbashi da inganta daidaitattun daidaito.
MC:
Kwamfutar hannu da ke ɗaure:
Ana amfani da MC azaman mai ba da labari a cikin tsarin kwamfutar hannu. Yana ba da kyakkyawan tsari da ƙarfin injiniya ga allunan, tabbatar da amincinsu yayin sarrafawa da ajiya.
Wurantragrant:
A wasu halaye, MC na iya yin aiki azaman rarrabuwa, taimaka wa allunan don rushe cikin ƙananan gastic, ta kuma gyara sakin kwayoyi.
Masu sarrafawa na Saki:
Kodayake ƙasa da kowa da hpmc, MC za a iya amfani da MC a cikin tsarin saki mai sarrafawa. Za'a iya amfani da kayan aikin thermogeal don sarrafa bayanin saki.
Thickening da karfafa wakili:
Ana amfani da MC a matsayin lokacin farin ciki da tsayayyen wakili a cikin ruwa daban-daban da Semi-ƙarfi. Ikonsa na ƙara danko yana taimakawa wajen ci gaba da kwanciyar hankali da kuma daidaituwar samfurin.
Takamaiman aikace-aikace a cikin harhada magunguna
Aikace-aikacen HPMC:
Shirye-shiryen ophthalmic:
Ana amfani da HPMC akai-akai a cikin mafita na oppthalmic da kuma gels saboda abubuwan lubricting da kayan ganima. Yana bayar da riƙewar danshi mai riƙe da lokacin tuntuɓar magani tare da octular farfajiya.
Tsarin Isar da Transdermal:
HPMC yana aiki a cikin facin canji wanda fim dinta-samar da ikon samar da matrix mai sarrafawa don isar da kwayoyi ta fata.
Kayayyakin mucoadhes:
Abubuwan da kadarorin mucoadhes na HPMC suka dace da kwasfa, hanci, da kuma farjin kwayoyi miyagun ƙwayoyin cuta, inganta lokacin zama a shafin aikace-aikace.
Aikace-aikace MC:
Topical formulars:
Ana amfani da MC a cikin cream ɗin magana, Gels, da maganin shafawa inda yake aiki a matsayin lokacin da yake ambaliya da haɓaka wakili, haɓaka wakili da daidaito na samfurin.
Abinci da kayan abinci:
Tun daga magunguna, MC ta samo aikace-aikace a abinci da kayayyakin abinci mai narkewa a matsayin Thingerener, mai ba da gudummawa ga matattarar kayayyaki daban-daban.
A taƙaice, HPMC da MC duka suna da ƙima sel mai mahimmanci tare da halaye daban-daban wanda ya sa ya dace da aikace-aikacen magunguna daban-daban. HPMC, tare da siyar da ruwa mai zafi a cikin zafi da sanyi, mafi girman girman kayan aiki, musamman falala a kan saki saki, kwamfutar hannu, da kuma shirye-shiryen OPHthmalm. MC, yayin da yake sauƙaƙa a cikin abun da ke ciki, yana daɗaɗawa na musamman a cikin ƙima mai sanyi da ƙananan yanayin gelation, da kuma m, da wakili na musamman a takamaiman aikace-aikace. Fahimtar bambance-bambance a cikin tsarin sunadarai, kaddarorin jiki, da ayyukan da suka dace suna ba da izinin yin amfani da samfuran samfuran masana'antu da suka dace.
Lokaci: Feb-18-2025