Magunguna masu commaceuticical sune compifies da ƙari ana amfani dasu a cikin samar da magunguna da magunguna, kuma muhimmin bangare ne na shirye-shiryen shirye-shirye. A matsayin kayan polymer na halitta da aka samo, eth ether ne bioshebable, wanda ba mai arha, pelyplel cellose, selyroxypyplellyl Preelchulose, sodroxypypireth sel methyl da selloxyl celboulose, sedixulose sel methyl da selloxyl celboulose, sedixulose sel magungunan magunguna. A halin yanzu, samfuran yawancin masana'antar erher ana amfani da su sosai a tsakiyar da filayen masana'antu, da darajar da aka kara ba ta da yawa. Masana'antu da saurin bukatar canji da haɓakawa don inganta babban aikace-aikacen samfuran.
Damar kasuwar magudi mai yawa ce
Magungunan magunguna suna taka muhimmiyar rawa a cikin ci gaba da samar da tsari. Misali, a cikin shirye-shiryen saki, kayan polymer kamar ether na saki, shirye-shiryen saki, da kuma ci gaba da shirya shirye-shiryen saki da dorewa. Shirye-shirye da ruwa mai dorewa shirye-shiryen saki an yi amfani da su. A cikin wannan tsarin, polymers kamar ether an yi amfani da ether a matsayin masu ɗaukar magunguna don sarrafa raguwar sakin jiki, ana buƙatar sakin jiki a cikin wani yanki a cikin wani yanki don cimma manufar ingantaccen magani.
A cewar kididdigar daga Sashen Bincike na Zhiyan, akwai kusan nau'ikan cirewa guda 500 waɗanda aka jera a cikin ƙasata (fiye da na biyu), da har yanzu suna da babban rata, da nau'ikan har yanzu sun zama ƙarami. Matsalar cigaban kasuwar babbar kasuwa ce. An fahimci cewa manyan comarfin magunguna na magunguna goma a cikin girman kasuwancin na sune, coppylendi, 1,2-propalendixypropyl methylcele, 1,2-propalendixypropyl 1,2-propalendixypropyl 1,2-propalendixypolyl
Sel sel shida commulose ether
Elell na halitta prelulose prether shine gaba ɗaya don jerin abubuwan da aka samar da sel wanda aka samar ta hanyar maganin alkali sel selulose da Eter na ETERION. Samfuri ne wanda ƙungiyoyin hydroxyl akan sel macromeleces macromecoleces ba wani bangare ko kuma gaba ɗaya ƙungiyoyi sun maye gurbinsu gaba ɗaya. Cellulose ehers ana amfani da shi sosai a cikin filayen man fetur, kayan gini, mayafi, abinci, magani, da magunguna na yau da kullun. A cikin filaye daban-daban, samfuran maganganun magunguna suna da asali a tsakiyar da filayen filayen masana'antu, tare da ƙara darajar girma. Saboda buƙatun ingancin yanayi, samar da ethulocous eth ether ma yana da wahala. Ana iya faɗi cewa ingancin samfuran magunguna na iya wakiltar ƙarfin fasaha na kamfanonin Elerulose. Yawancin ether ana ƙara ether a matsayin mai ba da labari, kayan matrix da thickener don haɓaka kayan fim, ci gaba da sakin kayan masarufi, da sauransu.
Sodium carboxymohyl sel akwatin
Carboxymose soum Sirtloum (CMC-Na) shi ne eth ether da mafi girma samarwa da kuma amfani a gida da kuma kasashen waje. Ita ce sel mai sel mai kyau ce daga auduga da itace ta alkalization tare da acid chloroaceticic acid. Cmc-na wani abu ne wanda aka saba amfani da magudi mai amfani. Ana amfani dashi sau da yawa azaman keɓaɓɓen shirye-shirye don shirye-shirye-ƙara, thickening da kuma matsakaiciyar matrix da kayan sihiri da kayan samar da fim. Ana amfani da shi sau da yawa azaman kayan samar da kayan aikin ƙwayoyin cuta da dorewa a cikin kwamfutar hannu mai ɗorewa cikin kayan kwalliya (masu sarrafawa).
Baya ga sodium carboxylcelllulose a matsayin compceutholical compide, za a iya amfani da sodium crarcarmolose a matsayin compceuticical compectical. Croscarose sodium ruwa (ccmc-na) wani samfurin mai ruwa ne na carboxcelcelous yana maido da wakilin haɗin kai a wani zazzabi mai kara a cikin wani masarautar mai cin abinci da kuma tsarkake shi. Kamar yadda wakili na Croslinking, propylene glycol, propcincinic anhydride, maleic anhydride da adipic an yi amfani da shi. Ana amfani da sodium na croscarhose azaman lalacewa don allunan, capsules da granules a cikin shirye-shiryen baka. Ya dogara da shiguwa da tasirin kumburi don rushewa. Yana da ingantaccen shafi da ƙarfi da ƙarfi. Karatun ya nuna cewa digiri na croscarmose sodium a cikin ruwa ya fi na sodium carmilulose.
Methylcelos
Methyl Slellulose (MC) Slelulose ne wanda ba na pel ethulose guda ɗaya da aka yi daga auduga da itace ta alkalization ehlorsification. Methylcelos yana da kyakkyawan abincin ruwa kuma yana da tsayayye a cikin kewayon PH2.0 ~ 13.0. Ana amfani dashi da yawa a cikin magudi mai yawa, kuma ana amfani dashi a cikin allunan intlingual, incramusculululululululululadic, baƙar fata, alloli na baka, allunan baka da shirye-shirye da shirye-shiryen baka. Bugu da kari, a cikin shirye-shirye-saki, MC za a iya amfani dashi azaman kayan saki gel matrixhilic gel matrixhilic gel Matrix
Dandaskin
Hydroxypyl methylcelose (hpmc) Cellulose ne wanda ba ionic ba shi ne gaurayar ether da aka yi daga auduga da itace ta hanyar shafawa, propylene opyl chlorisifer. Ba shi da kamshi, mai ƙanshi, wanda ba mai guba ba, mai narkewa a cikin ruwan sanyi kuma ya shafe shi cikin ruwan zafi. Hydroxypyl methyplulose shine sel gauraye nau'i-nau'i wanda samarwa, kashi da inganci sun kasance da sauri a cikin shekaru 15 da suka gabata. Hakanan yana daya daga cikin mafi yawan cirewa na magunguna a gida da kasashen waje. shekaru na tarihi. A halin yanzu, aikace-aikacen HPMC galibi suna nuna a cikin fannoni biyar masu zuwa:
Daya shine a matsayin m da wungiyoyi. A matsayin m, hpmc na iya sa ƙwayoyi sauƙin juye, kuma yana iya fadada daruruwan lokuta bayan shan ruwa, saboda haka zai iya inganta raguwar rushewa ko ƙimar kwamfutar hannu. HPMC tana da danko mai ƙarfi, wanda zai iya haɓaka danko da ƙwayar cuta kuma inganta haɗin kayan albarkatun ƙasa tare da kintsattse ko kuma kayan rubutu. HPMC tare da ƙarancin danko za a iya amfani dashi azaman m da m da rushewa, kuma waɗanda ke da ingantaccen danko za a iya amfani da shi azaman bood.
Na biyu shine azaman kayan saki da sarrafawa don shirye-shiryen baka na baka. HPMC wani abu ne wanda aka saba amfani da matrix na zamani a cikin shirye-shiryen saki. Za'a iya amfani da low-danko (5-50mpph · s) a matsayin Bodind, Vischifier Motsa Wifs, 4000-100000mpAn Wuya mai hade da shi. HPMC yana da narkewa a cikin ruwa na ciki, yana da fa'idodi na ɗimbin ɗawa, mai kyau, mai ƙarfin ɗagawa, da halaye na ƙwayoyi da ƙwayoyi ba shafa da PH ba. Yana da matukar muhimmanci a sanya kayan masarufi a cikin tsarin shirye-shiryen saki kuma galibi ana amfani dashi azaman kayan aikin saki, da kuma kayan kwalliya na shirye-shiryen saki na kwastomomi.
Na uku shine a matsayin mai tsara wakilin fim. HPMC yana da kayan aikin fim mai kyau. Fim da aka kafa ta shi ne uniform, m da tauri, kuma ba abu mai sauƙi ba ne a lokacin samarwa. Musamman ma magunguna waɗanda ke da sauƙin ɗauka danshi kuma ba su da m, ta amfani da shi azaman na warewar magani kuma yana iya canza fim ɗin yana canza launi. HPMC tana da bayanan danko daban-daban. Idan aka zaɓi yadda yakamata, inganci da bayyanar allunan da aka hade su da fifikon wasu kayan. Ainihin amfani da maida hankali ne 2% zuwa 10%.
Na huɗu shine a matsayin kayan capsule. A cikin 'yan shekarun nan, tare da barkewar m barkewar abubuwan annoben dabbobi na duniya, idan aka kwatanta da Gelatin Capsules, kayan lambu kayan lambu sun zama sabon masana'antar abinci da kayan abinci. Dan kasar Amurka ya samu nasarar fitar da HPMC daga tsire-tsire na halitta daga tsire-tsire da shirye Vcaptm kayan lambu capsules. Idan aka kwatanta da gelatin gargajiya na gargajiya, capsules shuka suna da fa'idodin abubuwan daidaitawa da ke da alaƙa, babu haɗarin tsallakewa da mahalarta. Kimar ƙwayoyi ba shi da tabbaci, kuma bambance-bambance na mutum ƙananan ne. Bayan rushewa a cikin jikin mutum, ba a sha ba kuma ana iya magance abu wanda aka cire daga jiki. Dangane da yanayin ajiya, bayan yawan gwaje-gwaje, kusan ba su da ƙarfi a ƙarƙashin yanayin ƙarancin zafi, kuma alamuran capsules na capsule ba su shafi kullun capsules ba su shafa a ƙarƙashin matsanancin yanayin ajiya ba. Tare da fahimtar mutane da capsules da canjin manufar aikin jama'a a gida da waje, kasuwancin da ake buƙata na capsules na shuka zai yi girma cikin sauri.
Na biyar shine wakili na dakatarwa. Shirya ruwa mai ruwa mai ruwa ne wanda aka saba amfani da shi na yau da kullun, wanda shine tsarin wutsiya na haɗari wanda ba a watsa shi mai ƙarfi a cikin matsakaici na watsawa. Dankar tsarin yana tantance ingancin dakatarwar ruwa. Magani na HPMC na iya rage tashin hankali mai ƙarfi-ruwa, rage saman kuzarin kyauta na m barbashi, kuma yana da alaƙa da tsarin wretogeneus. Wakilin dakatarwa ne. Ana amfani da HPMC azaman thickener don murfin ido, tare da abun ciki na 0.45% zuwa 1.0%.
Selpyp pelloxropyp
Slerlulosepropyl Slellulose (HPC) sel mara kyau ne mara kyau ether da aka yi daga auduga da itace ta hanyar alkyalization da propylene baki extheide. HPC yawanci narkewa ne a cikin ruwa a ƙasa 40 ° C da kuma yawan adadin abubuwan sha-da-polar, kuma wasan kwaikwayonta yana da alaƙa da abubuwan da ke tattare da ƙungiyar Hydroxypyl da kuma matsayin polymerization. HPC na iya dacewa da kwayoyi daban-daban kuma yana da meteriya.
Anyi amfani da pel mai ƙarancin ƙwayar cuta ta ruwa mai ƙarfi. -HPC na iya inganta wuya da kuma kwamfutar hannu na kwamfutar hannu, kuma yana iya sanya kwamfutar hannu ta rushe da sauri, haɓaka ingancin Cikin gida, da haɓaka tasirin curative.
A sosai sydroxypropyl Prealllululose cel (H-HPC) za a iya amfani dashi azaman boye don allunan, granules, da kyawawan mafarauta a filin wasan magunguna. H-HPC tana da kyawawan kayan fim-forming, kuma fim ɗin da aka samu yana da wuya da na roba, wanda za'a iya kwatanta shi da filastik. Aiwatar da fim zai iya ƙara inganta ta hanyar haɗuwa tare da wasu masu tsayayya da wakilan danshi, kuma ana amfani dashi azaman kayan fim don allunan fim don allunan. Hakanan za'a iya amfani da HPC azaman kayan matrix don shirya matrix na ci gaba da sakin allon, dorewa-saki pellets da allon saki sau biyu.
Slell Pelloxyl Sel
Sellululose na Slal -Lulose (HEC) shine sel mai-kai ba ethululose guda ɗaya da aka yi daga auduga da itace ta hanyar alkurali da ethatulation na ethylene oxide. A cikin filin Magunguna, an yi amfani da HEC galibi azaman ƙarar ƙwayar cuta, wakili, mai narkewa, kwamfutar hannu, daskararru, tebur mai ɗorewa, capsule da sauran siffofin sashi. An yi rikodin Sellulose na Slugha na Hydroosea a cikin Tsarin Pharmacopoeia / Tsarin Kasa da Kasa na Turai da Magunguna na Turai, da sauransu.
Ethlulose
Eltyl Sellulose (EC) shine ɗayan mafi yawan amfani da ruwan shinken ruwan sama wanda aka fi sani da ruwa. EC ba mai guba bane, barga, insolble cikin ruwa, acid ko alkali bayani, da kuma narkewa a cikin kwayoyin cuta irin su kamar ethanol. Mafi yawan amfani da sauran ƙarfi shine Toluene / ethanol azaman 4/1 (nauyi) gauraye ga sauran ƙarfi. EC yana da amfani da yawa a cikin shirye-shiryen saki na ci gaba, microcaules, da kuma shafi kayan saki mai ɗorewa don ci gaba da shirye-shiryen saki, da aka yi amfani da shi pellets, amfani da azaman kayan taimako na taimako don shirya cizon microcaules; Hakanan za'a iya amfani dashi sosai azaman kayan ɗaukar abu don shirye-shiryen m watsun; Amfani da shi sosai a cikin fasahar magunguna a matsayin abu mai inganci da kayan kariya, da kuma a matsayin m da kuma filler. Kamar yadda kayan haɗin kwamfutar hannu, zai iya rage m na kwamfutar hannu zuwa zafi kuma hana magani daga cikin abin da ya shafa ta danshi, discolororation da lalacewa; Hakanan zai iya samar da jinkirin sakin gel, microenciapsate polymer, kuma kunna m saki a sakamakon miyagun ƙwayoyi.
Rabu da Aikace-aikacen Karshe da Inganta Canza da Ingantawa
In summary, water-soluble sodium carboxymethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose and oil-soluble ethyl cellulose all use their respective It is used in pharmaceutical excipients as binders, disintegrants, sustained and Abubuwan da ke sarrafawa don shirye-shiryen baka, suna ɗora wakilai na fim, kayan capsule da wakilan dakatarwa. Kallon duniya, kamfanonin ƙasashe da yawa (kamfanoni na ƙasashen waje (Shin-Etu Japan, Dow Wolfe da Ashland giciye Dragonulose) sun fahimci babban kasuwar PRALUCELANE) sun fahimci babban kasuwar sel ta samu, kuma sun karu da kokarinsu a wannan fannin. shigarwar aikace-aikace a ciki. Ya Wolfe ya sanar da cewa zai karfafa ya mayar da hankali kan kirkira, Sinadaran da kuma neman amfani da tsarin aikin Charmacectical shirin. Dace Smiler Chemin Slelff Sihiri da Kamfanin Kasar Amurka sun kafa kamfanoni daban-daban da kuma masana'antu 15, da yawaitar kwararru na amfani da wasu kasashe 160. Ashland tana da tushen samar da kayayyaki a cikin birnin Beijing, Tianjin, Shanghai, Nanjing, Kunshhou, Kundchan da Jiangmen, kuma ya kashe a cibiyoyin fasaha uku a Shanghing.
A cewar kididdigar daga shafin yanar gizon Selangonungiyar Celullulose, a cikin 2017, samar da gida na eth ether 373,000 ne tan 360,000 tan 36,000 tan. A shekara ta 2017, ainihin tallace-tallace na ƙwararrun tallace-tallace na Ionic CMC ya kasance tan 234,000 shekara-shekara, da karuwar shekara ta ionic, wani shekara-shekara-shekara-shekara. Baya ga HPMC (Gwajin kayan gini), kayayyakin ionic, HPMC (sahun abinci), HPMC (sa), HPC, HPC, da sauransu, da sauransu, da sauransu, da sauransu. Elerlulose Elerlulose Erhery ya girma cikin hanzari fiye da shekaru goma, kuma fitarwa ta zama farkon duniya. Koyaya, samfuran yawancin kamfanonin ether ana amfani da su sosai a tsakiyar da ƙananan filayen masana'antu, da kuma darajar da aka kara ba ta da yawa.
A halin yanzu, yawancin kamfanonin Cellulose na gida suna cikin matuƙar lokacin canji da haɓakawa. Yakamata su ci gaba da kara yawan binciken samfuri da kokarin ci gaba, ci gaba da haɓaka ci gaba da haɓaka a duniya, da kuma samun dama na masana'antu, da kuma cimma nasara a fagen masana'antu.
Lokaci: Jun-15-2023