Menene HPMC?

HPMC Hydroxypropyl methylcellulose, kuma aka sani da hypromellose, yana ɗaya daga cikin ethers ɗin da ba na ionic cellulose ba.Semi-synthetic ne, mara aiki, polymer viscoelastic da aka saba amfani dashi azaman mai mai a cikin ilimin ido, ko azaman mai haɓakawa ko mai haɓakawa a cikin magungunan baka.

Sunan samfurin Hydroxypropyl methyl cellulose (HPMC)
Wani suna Hydroxypropyl methylcellulose,MHPC, methyl Hydroxypropyl cellulose
Lambar Rijistar CAS 9004-65-3
Bayyanar fari fibrous ko granular foda
bayanin aminci S24/25

The jiki da kuma sinadaran Properties
Bayyanar: fari ko kusan fari fibrous ko granular foda
Ƙarfafawa: Ƙaƙƙarfan ƙaƙƙarfan wuta ne kuma ba su dace da masu ƙarfi masu ƙarfi ba.
Granularity;Adadin wucewa na raga 100 ya fi 98.5%.Adadin wucewa na idanu 80 shine 100%.Girman musamman na girman barbashi 40 ~ 60 raga.
Carbonization zafin jiki: 280-300 ℃
Matsakaicin bayyane: 0.25-0.70g/cm3 (yawanci kusan 0.5g/cm3), ƙayyadaddun nauyi 1.26-1.31.
Canjin launi: 190-200 ℃
Tashin hankali: 42-56dyne/cm a cikin 2% bayani mai ruwa
Solubility: mai narkewa a cikin ruwa da wasu kaushi, kamar daidai gwargwado na ethanol / ruwa, propanol / ruwa, da dai sauransu. Aqueous bayani yana da surface aiki.High nuna gaskiya, barga yi, daban-daban bayani dalla-dalla na samfurin gel zafin jiki ne daban-daban, solubility canje-canje tare da danko, da ƙananan danko, da mafi girma da solubility, daban-daban bayani dalla-dalla na HPMC yi yana da wani bambanci, HPMC bayani a cikin ruwa ba ya shafa. pH darajar.
Ayyukan saman na HPMC sun ragu tare da raguwar abun ciki na methoxyl, karuwar ma'anar gel da raguwar solubility na ruwa.
Har ila yau, HPMC yana da ikon yin kauri, juriya na gishiri low ash foda, pH kwanciyar hankali, riƙewar ruwa, kwanciyar hankali mai girma, kyakkyawan fim ɗin da aka kafa, da kuma yawan juriya ga enzyme, rarrabawa da halayen haɗin kai.

Hanyoyin samarwa
The mai ladabi cellulose auduga ana bi da tare da lye a 35-40 ℃ na rabin sa'a, guga man, da cellulose ne crushed da kuma shekaru a 35 ℃, sabõda haka, matsakaicin polymerization digiri na alkali fiber samu ne a cikin da ake bukata kewayon.Saka alkali fiber a cikin kettle etherification, ƙara propylene oxide da methane chloride jere, etherize a 50-80 ℃ na 5h, mafi girma matsa lamba ne game da 1.8mpa.Sa'an nan kuma ƙara daidai adadin hydrochloric acid da oxalic acid kayan wankewa a cikin 90 ℃ ruwan zafi don ƙara girma.Lokacin da abun ciki na ruwa a cikin abu bai wuce 60% ba, an bushe shi zuwa ƙasa da 5% ta hanyar iska mai zafi a 130 ℃.A ƙarshe, ana murƙushe samfurin da aka gama kuma an duba shi ta hanyar raga 20.

Hanyar warwarewa
1, duk samfurori za a iya ƙarawa zuwa kayan ta hanyar hanyar hadawa bushe.
2, buƙatar ƙara kai tsaye zuwa maganin ruwan zafin jiki na al'ada, yana da kyau a yi amfani da tarwatsawar ruwan sanyi, bayan ƙara gabaɗaya a cikin mintuna 10-90 don kauri.
3. Za'a iya narkar da samfurori na yau da kullum bayan haɗuwa da watsawa da ruwan zafi da kuma ƙara ruwan sanyi bayan motsawa da sanyaya.
4. Lokacin narkar da, idan abin mamaki na agglomerating faruwa, shi ne saboda hadawa bai isa ba ko talakawa model an kai tsaye ƙara zuwa ruwan sanyi.A wannan lokacin, ya kamata a motsa shi da sauri.
5. Idan kumfa ya faru a lokacin rushewa, ana iya cire su ta hanyar tsayawa na tsawon sa'o'i 2-12 (ƙayyadaddun lokaci ya dogara da daidaito na maganin) ko ta hanyar vacuumizing da matsawa, ko ta ƙara adadin da ya dace na defoaming wakili.

Ana amfani da HPMC
An yi amfani da shi azaman mai kauri, watsawa, ɗaure, excipant, mai juriya mai, filler, emulsifier da stabilizer a masana'antar yadi.Hakanan ana amfani dashi sosai a cikin guduro roba, petrochemical, yumbu, takarda, fata, magani, abinci da kayan kwalliya da sauran masana'antu.

Babban manufar
1, masana'antar gine-gine: azaman siminti turmi mai riƙe da ruwa, turmi retarder tare da yin famfo.A cikin plastering, gypsum, putty foda ko wasu kayan gini a matsayin m, inganta daub da tsawaita lokacin aiki.An yi amfani da shi don liƙa tayal yumbu, marmara, kayan ado na filastik, wakili mai ƙarfafa manna, har yanzu yana iya rage yawan siminti.Ayyukan riƙe ruwa na HPMC yana sa slurry bayan aikace-aikacen ba zai zama saboda bushewa da sauri da fashe ba, haɓaka ƙarfi bayan taurin.
2, yumbu masana'antu: yadu amfani da matsayin m a yumbu samfurin masana'antu.
3, masana'antu mai rufi: a cikin masana'antar sutura a matsayin mai kauri, mai rarrabawa da kuma stabilizer, a cikin ruwa ko masu kaushi na kwayoyin halitta suna da kyakkyawan solubility.A matsayin mai cire fenti.
4, tawada bugu: a cikin tawada masana'antu a matsayin thickener, dispersant da stabilizer, a cikin ruwa ko Organic kaushi da mai kyau solubility.
5, filastik: don kafa wakili na saki, softener, mai mai, da dai sauransu.
6, PVC: PVC samar a matsayin dispersant, dakatar polymerization shiri na PVC main auxiliaries.
7, Pharmaceutical masana'antu: shafi kayan;Abun ƙwayar cuta;Abubuwan da ake sarrafa ƙimar polymer don shirye-shiryen ɗorewa-saki;Wakilin daidaitawa;Taimakon da aka dakatar;Tablet m;Yana ƙara guguwa
8, Wasu: Har ila yau, ana amfani da su sosai a cikin fata, masana'antun kayan aikin takarda, adana 'ya'yan itace da kayan lambu da masana'antar yadi.

Aikace-aikacen masana'antu na musamman

Masana'antar gine-gine
1, ciminti turmi: inganta watsar da siminti - yashi, ƙwarai inganta roba da kuma ruwa riƙe da turmi, don hana fasa yana da tasiri, zai iya inganta ƙarfin ciminti.

2, yumbu tile ciminti: inganta plasticity na yumbu tayal turmi, ruwa riƙewa, inganta manne gudun ba da sanda na yumbu tayal, hana foda.
3, asbestos da sauran refractory shafi: a matsayin mai dakatarwa wakili, liquidity inganta wakili, amma kuma inganta tushe na manne gudun ba da sanda.
4, gypsum slurry: inganta riƙewar ruwa da kuma aiwatarwa, inganta mannewa na tushe.
5, simintin haɗin gwiwa: ƙara a cikin jirgi na gypsum tare da ciminti na haɗin gwiwa, inganta ruwa da riƙe ruwa.
6, Latex putty: inganta haɓakar ruwa da riƙe ruwa na tushen latex na tushen sa.
7, turmi: a matsayin madadin na halitta manna, iya inganta ruwa riƙewa, inganta manne gudun ba da sanda tare da tushe.
8, shafi: a matsayin plasticizer na latex shafi, yana da wani rawa wajen inganta aiki yi da fluidity na shafi da putty foda.
9, fesa shafi: don hana ciminti ko fesa latex kawai nutsewar kayan maye da haɓaka kwararar filaye da zane-zanen katako suna da tasiri mai kyau.
10, ciminti, gypsum na biyu kayayyakin: kamar yadda ciminti - asbestos da sauran na'ura mai aiki da karfin ruwa kayan latsa gyare-gyaren ɗaure, inganta fluidity, iya samun uniform gyare-gyaren kayayyakin.
11, bangon fiber: saboda tasirin anti-enzyme anti-kwayan cuta, kamar yadda mai ɗaure bangon yashi yana da tasiri.
12, wani: za a iya amfani da shi azaman siririyar turmi turmi da aikin turmi na wakilin kumfa.

Masana'antar sinadarai
1, vinyl chloride, vinyl polymerization: kamar yadda polymerization dakatar stabilizer, dispersant, tare da vinyl barasa (PVA) hydroxypropyl cellulose (HPC) da kuma iya sarrafa rarraba barbashi siffar da barbashi.
2, m: azaman fuskar bangon waya m, maimakon sitaci yawanci ana iya amfani da shi tare da vinyl acetate latex shafi.
3. Maganin kashe qwari: kara wa magungunan kashe qwari da magungunan kashe qwari, zai iya inganta tasirin adhesion lokacin fesa.
4, Latex: inganta kwalta emulsion stabilizer, styrene butadiene roba (SBR) latex thickener.
5, mai ɗaure: a matsayin fensir, crayon yana samar da m.

Masana'antar kayan shafawa
1. Shampoo: inganta danko da kwanciyar hankali na kumfa na shamfu, wanka da wanka.
2. Man goge baki: Inganta yawan ruwan man goge baki.

Masana'antar abinci
1, Citrus gwangwani: hana a kiyayewa saboda bazuwar glycosides na orange da farar fata don cimma sabo.
2, samfuran 'ya'yan itace masu sanyi: ƙara cikin raɓar 'ya'yan itace, matsakaicin ƙanƙara, sanya dandano mafi kyau.
3, miya: kamar miya, tumatir miya emulsifying stabilizer ko thickening wakili.
4, ruwan sanyi shafi glazing: amfani da daskararre kifi ajiya, iya hana discoloration, ingancin ragewa, tare da methyl cellulose ko hydroxypropyl methyl cellulose bayani mai rufi glazing, sa'an nan daskarewa a kan kankara.
5, manne da kwayoyi: kamar yadda ake samar da kwayoyin kwayoyi da kwayoyi, hadewa da rugujewa (da sauri narke da watsewa yayin shan) yana da kyau.

Masana'antar harhada magunguna
1. Shafi: da shafi wakili da aka sanya a cikin wani Organic sauran ƙarfi bayani ko ruwa ruwa bayani ga Allunan, musamman ga barbashi sanya na fesa shafi.
2, rage jinkirin wakili: 2-3 grams kowace rana, kowane lokaci 1-2G sashi, a cikin kwanaki 4-5 don nuna sakamako.
3, maganin ido: saboda matsawar osmotic na hydroxypropyl methyl cellulose aqueous bayani iri ɗaya ne da hawaye, don haka yana da ƙananan idanu, ƙara magungunan ido, a matsayin mai mai don tuntuɓar ruwan ido.
4, gelatinous wakili: a matsayin tushe abu na gelatinous waje magani ko maganin shafawa.
5, Magunguna masu ciki: a matsayin wakili mai kauri, wakili mai riƙe ruwa.

Masana'antar makera
1, kayan lantarki: azaman denser na yumbu na lantarki, bauxite ferrite gyare-gyaren matsa lamba na magnetic, ana iya amfani dashi tare da 1.2-propylene glycol.
2, glaze: amfani da yumbu glaze da ain tare da enamel, iya inganta bonding da processability.
3, turmi refractory: ƙara a cikin turmi refractory ko simintin tanderu abu, zai iya inganta robobi da ruwa riƙewa.

Sauran masana'antu
1, fiber: kamar yadda bugu mai rini ga pigments, boron gandun daji dyes, gishiri tushen dyes, yadi, bugu da kari, a cikin kapok ripple aiki, za a iya amfani da zafi hardening guduro.
2, takarda: amfani da carbon takarda fata gluing da mai sarrafa man da sauran al'amurran.
3, fata: a matsayin man shafawa na ƙarshe ko amfani da mannewa.
4, ruwa na tushen tawada: ƙara zuwa ruwa na tushen tawada, tawada, kamar yadda thickening wakili, fim kafa wakili.
5, taba: a matsayin mannen taba sigari.

Ma'aunin Pharmacopoeia

Tushen da abun ciki
Wannan samfurin shine 2- hydroxypropyl ether methyl cellulose.Hydroxypropyl methylcellulose za a iya raba hudu iri bisa ga abun ciki na methoxy da hydroxypropyl, wato 1828, 2208, 2906, 2910. Abun ciki na kowane methoxy maye gurbinsu (-OCH3) da hydroxypropoxy (-OCH2ChohCH3) ya kamata a haɗe da tanadi. tebur.

hali
Wannan samfurin fari ne ko fari-farin fibrous ko granular foda;Mara wari.
Wannan samfurin yana kusan rashin narkewa a cikin ethanol, ether da acetone;Kumburi a cikin ruwan sanyi don samar da maganin colloid bayyananne ko dan kadan.

Don ganewa
(1) Ɗauki 1g na samfurin, zafi 100mL na ruwa (80 ~ 90 ℃), motsawa akai-akai, sanyi a cikin wanka na kankara, da kuma samar da ruwa mai laushi;Saka 2ml na maganin a cikin bututun gwaji, a hankali ƙara 1mL na 0.035% anthracene sulfuric acid maganin anthracene tare da bangon bututu, sanya shi tsawon mintuna 5, kuma zoben shuɗi-kore ya bayyana a wurin haɗin tsakanin ruwaye biyu.
(2) Adadin da ya dace na ruwan danko a ƙarƙashin ganewa (1) ana zuba akan farantin gilashi.Bayan fitar da ruwa, an kafa wani Layer na fim mai tauri.

duba
1, ph
Bayan sanyaya, daidaita bayani zuwa 100g tare da ruwa da motsawa har sai an narkar da shi gaba daya.Ƙaddara bisa ga doka ( Shafi ⅵ H, Sashe na II na Pharmacopoeia, 2010 edition).PH yakamata ya zama 5.0-8.0.
2, dankowa
2.0% (g / g) dakatar da aka shirya ta hanyar shan 10.0g na samfurin da kuma ƙara 90 ℃ ruwa don yin jimlar nauyin samfurin da ruwa 500.0g a matsayin busassun samfurin.An jujjuya dakatarwar gabaɗaya na kusan mintuna 10 har sai an tarwatsa ɓangarorin gaba ɗaya kuma an jika.An kwantar da dakatarwar a cikin wanka na kankara kuma ya ci gaba da motsawa na tsawon mintuna 40 yayin aikin sanyaya.Silinda rotary viscosimeter guda ɗaya (ndJ-1 za a iya amfani dashi don samfurori tare da danko ƙasa da 100Pa·s, kuma ana iya amfani da NDJ-8S don samfurori tare da danko mafi girma ko daidai da 100Pa·s, ko wasu ingantattun viscosimeter masu dacewa) an yi amfani da shi a 20 ℃ ± 0.1 ℃, ƙaddara bisa ga doka (hanyar ⅵ G ta biyu a shafi na II na Pharmacopoeia 2010 edition).Idan danko mai lakabin bai wuce 600mPa·s, danko ya kamata ya zama 80% ~ 120% na danko mai lakabin;Idan danko mai lakabin ya fi ko daidai da 600mPa·s, danko ya kamata ya zama 75% zuwa 140% na danko mai lakabin.

3 Al'amarin da ba ya narkewa a cikin ruwa
Sai ki dauko 1.0g na samfurin, sai ki zuba a cikin kwano, a zuba ruwan zafi 100ml a 80-90 ℃, sai a kumbura kamar minti 15, sai a sanyaya a cikin wankan kankara, sai a zuba ruwa 300mL (idan ya cancanta, sai a kara yawan ruwa yadda ya kamata. a tabbatar an tace maganin), sannan a motsa shi sosai, a tace shi ta hanyar no.Gilashin narkewar gilashin tsaye 1 wanda aka bushe zuwa nauyi akai-akai a 105 ℃, kuma tsaftace beaker da ruwa.An tace ruwan a cikin gilashin narkewar gilashin da ke sama a tsaye kuma an bushe shi zuwa tsayin daka a 105 ℃, tare da ragowar da bai wuce 5mg (0.5%) ba.

4 Busassun nauyi
Ɗauki wannan samfurin kuma a bushe shi a 105 ℃ na tsawon sa'o'i 2, kuma asarar nauyi ba za ta wuce 5.0% ba (Shafi ⅷ L, Sashe na II, Pharmacopoeia 2010 edition).

5 Ragowar kuna
Ɗauki 1.0g na wannan samfurin kuma duba shi bisa ga doka (Shafi ⅷ N, Sashe na II na pharmacopoeia 2010 edition), kuma ragowar ba za ta wuce 1.5% ba.

6 karfe mai nauyi
Ɗauki ragowar da aka bari a ƙarƙashin ragowar wuta, bincika daidai da doka (hanyar shafi na biyu na Karin bayani ⅷ H na kashi na biyu na bugu na 2010 na pharmacopoeia), mai ɗauke da ƙarfe mai nauyi kada ya wuce sassa 20 a kowace miliyan.

7 gishiri arsenic
Sai a dauki 1.0g na wannan samfurin, sai a zuba 1.0g calcium hydroxide, sai a gauraya, a zuba ruwa a rika motsawa daidai gwargwado, a bushe, da farko tare da karamin wuta zuwa carbonize, sa'an nan kuma a 600 ℃ a ƙone gaba daya ash, sanyaya, ƙara 5mL hydrochloric acid da 23ml ruwa. don narkar da, duba bisa ga doka (bugu na 2010 na pharmacopoeia ii Shafi ⅷ J hanya ta farko), ya dace da tanadi (0.0002%).

Ƙaddamar da abun ciki
1, methoxyl
Methoxy, ethoxy da hydroxypropoxy (shafi VII F, Sashe na II, 2010 Edition na Pharmacopoeia) an ƙaddara.Idan ana amfani da hanya ta biyu (hanyar juzu'i), ɗauki samfurin, auna shi daidai kuma auna shi bisa ga doka.Adadin methoxy da aka auna (%) an cire shi daga samfurin adadin hydroxypropoxy (%) da (31/75×0.93).
2, hydroxypropoxy
Methoxy, ethoxy da hydroxypropoxy (shafi VII F, Sashe na II, 2010 Edition na Pharmacopoeia) an ƙaddara.Idan aka yi amfani da hanya ta biyu (hanyar ƙara), ɗauki samfurin kamar 0.1g, auna daidai, ƙayyade bisa ga doka, kuma samu.

Pharmacology da toxicology
Hydroxypropyl methyl cellulose wani bangare ne na cellulose methyl da wani ɓangare na hydroxypropyl ether, ana iya narkar da shi a cikin ruwan sanyi don samar da wani danko bayani, da kaddarorin da hawaye a cikin viscoelastic abubuwa (yafi mucin) kusa, sabili da haka, za a iya amfani da wucin gadi. hawaye.Tsarin aikin shine cewa polymer yana manne da saman ido ta hanyar tallatawa, yana kwaikwayon aikin mucin conjunctival, don haka inganta yanayin rage ƙwayar ido da kuma ƙara tsawon lokacin riƙe ido a cikin yanayin raguwar hawaye.Wannan adsorption ya kasance mai zaman kanta daga danko na maganin kuma don haka yana ba da damar tasiri mai ɗorewa har ma don ƙananan ƙwararrun hanyoyin warwarewa.Bugu da ƙari, ana ƙara jika na ƙwanƙwasa ta hanyar rage kusurwar lamba na tsattsauran ma'auni.

pharmacokinetics
Ba a bayar da rahoton bayanan harhada magunguna don amfani da wannan samfurin a kai tsaye ba.

alamomi
Danka idanu tare da rashin isasshen hawaye kuma kawar da rashin jin daɗi na ido.

Amfani
Duk manya da yara suna iya amfani da shi.1-2 saukad da sau uku a rana;Ko kuma kamar yadda likita ya umarta.
Mummunan halayen gyara magana
A lokuta da ba kasafai ba yana iya haifar da rashin jin daɗi na ido kamar ciwon ido, duhun gani, dagewar cunkoso na haɗin gwiwa ko haushin ido.Idan alamun da ke sama sun bayyana a fili ko sun ci gaba, daina amfani da maganin kuma je asibiti don dubawa.
haramun

Contraindicated a cikin mutanen da ke fama da rashin lafiyar wannan samfurin.

Abubuwan da ke buƙatar kulawa
1. Kar a taɓa kan digowar kwalbar zuwa fatar ido da sauran wuraren don hana kamuwa da cuta
2. Da fatan za a kiyaye samfurin daga wurin yara
3. Wata daya bayan bude kwalban, bai dace da ci gaba da amfani da shi ba.
4. Magani ga mata masu juna biyu da masu shayarwa: ba a sami rahoton lalacewar haihuwa ko wasu matsalolin da HYDROXYpropyl cellulose ke haifarwa a jikin mutum ba;Ba a ba da rahoton wani mummunan sakamako a cikin jarirai a lokacin shayarwa ba.Saboda haka, babu wata takaddama ta musamman ga mata masu juna biyu da masu shayarwa.
5. Magani ga yara: idan aka kwatanta da sauran shekaru kungiyoyin, hydroxypropyl methylcellulose a cikin yara ba ya haifar da mafi m halayen.Don haka, yara da manya na iya amfani da wannan samfurin bisa ga tsari ɗaya.
6, magani ga tsofaffi: amfani da hydroxypropyl methylcellulose a cikin tsofaffi marasa lafiya, idan aka kwatanta da sauran kungiyoyi masu shekaru, baya haifar da cututtuka daban-daban ko wasu matsaloli.Saboda haka, magani na tsofaffi marasa lafiya ba su da contraindications na musamman.
7, ajiya: ajiyar iska.

Ayyukan aminci
Hadarin lafiya
Wannan samfurin yana da aminci kuma ba mai guba ba, ana iya amfani da shi azaman ƙari na abinci, babu zafi, babu haushi ga fata da ƙwayar mucous membrane.Gabaɗaya ana ɗaukar lafiya (FDA1985).Abubuwan da aka halatta a kullum shine 25mg/kg (FAO/WHO 1985).Ya kamata a sanya kayan kariya yayin aiki.

Tasirin muhalli
Ka guji gurɓatar iska da ƙura ke haifarwa.
Hatsari na jiki da na sinadarai: guje wa hulɗa da tushen wuta, da kuma guje wa yin ƙura mai yawa a cikin rufaffiyar muhalli don hana haɗarin fashewar abubuwa.
Ajiye kayan da aka aika
Kula da kariya ta rana daga ruwan sama da danshi, kauce wa hasken rana kai tsaye, an rufe shi a wuri mai bushe.
Zaman tsaro
S24/25: Guji hulɗa da fata da idanu.
Ka guji haɗuwa da fata da idanu.